Vitamin D receptor polymorphisms and vitamin D insufficiency are not associated with sepsis in critically ill children: a case-control study

Abstract Background Vitamin D is a fat-soluble vitamin that regulates calcium and phosphorous homeostasis to maintain healthy mineralized skeleton. It can also influence immune responses has immunomodulatory properties. receptor (VDR) nuclear mediates the activities of hormonal form D. VDR polymorphisms alter immunity susceptibility infections by modulating expression activity. This study aimed investigate levels serum as well four polymorphisms: FokI, BsmI, ApaI, TaqI in fifty children admitted intensive care unit (ICU) with diagnosis sepsis one-hundred age- sex-matched children. Methods were measured serum, both patients controls, using an enzyme-linked immunosorbent assay (ELISA) approach. studied groups specific restriction enzymes. Results low controls. Moreover, unaffected polymorphisms, their distribution was similar groups. Neither need for mechanical ventilation or inotropic treatment nor outcome impacted polymorphisms. Conclusion In pediatric ICU, neither associated sepsis. Further larger studies including different types are recommended.